Alexander's Way Research Fund is a nonprofit, charitable organization that promotes international collaboration among scientists, researchers, and patient advocacy groups, to speed up research, development, and delivery of treatments for children and adults affected by Bag3 myofibrillar myopathy (MFM6), and other neuromuscular diseases.
We depend on your contributions to fund advances in science with the aim of creating a cure.
Alexander’s Way is proud to be supporting the work of Dr. Igor F. Tsigelny in an exciting research project. This project aims at identifying compounds which interfere with the harmful action of a mutant protein (Bag3). Igor F. Tsigelny is a leading expert in structural biology, molecular modeling, bioinformatics, structure-based drug design, and molecular mechanisms of diseases. His computational study of molecular mechanisms of Parkinson’s disease has been included in the US Department of Energy publication “Decade of Discovery”, where the best computational studies of the decade 1999-2009 have been described. His area of expertise includes bioinformatics, structural biology, computational drug design, and molecular mechanisms of diseases.
In 2018 and 2019, Alexander’s Way supported a project to build a personalized genome engineering tool using the CRISPR/Cas9 technology. The goal was to silence or correct the mutation which is responsible for myofibrillar myopathy 6 (MFM6). Although the project shows some successful results, it is in the pre-clinical stage.
Dr. Jong-Min Lee, at the Massachusetts General Hospital and Harvard Medical School, leads the group.
A child diagnosed with this rare disease finds that the medical community does not have any treatment or cure. This reality is indeed cruel and unfair to the children and families affected. Tragically, in most known cases, the children have perished from this condition.
We are driven and motivated by a new philosophy. We are taking an active role in supporting scientific efforts to develop a cure for ourselves and others.
Click on the arrow below to learn more about this ultra-rare disease.
Marco's and Alexander's families are advocating and working together to overcome this disease. We will turn hope into reality for children and young adults with this condition.
With your support our organization will sponsor scientists directly, ensuring that resources are used in an effective way.
For the sake of our children and others...Please join us in these efforts !